USA Fairly Legal -- Ryan Johnson Joins Season 2 cast

USA Network?s Fairly Legal is expanding its ranks for Season 2, starting with the addition of Aussie actor Ryan Johnson as a new series regular.

An alum of such Down Under fare as Home and Away and Out of the Blue, Johnson will play Ben Grogan, a sharp, up-and-coming trial attorney who is not as concerned with ?the right and wrong? of a situation as he is maximizing his financial gain. Our sister site Deadline first reported on his casting.

Fairly Legal?s Sarah Shahi on Rumored Season 2 Fixes: There Are Things We Could Do Better

Sources tell TVLine that Ben could emerge as a possible new romantic interest for series lead Sarah Shahi?s Kate, with whom he will at times?professionally spar.

Matt?s Inside Line: Scoop on Fairly Legal?s Season 2 Premiere

A premiere date for Fairly Legal?s sophomore run, which began production today, has yet to be announced, though it should be in early 2012.

Want Scoop and Spoilers Sent Directly to Your In-Box? Sign Up for the TVLine Newsletter Now!

Source: http://www.tvline.com/2011/10/usa-network-fairly-legal-season-2-ryan-johnson/

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Alien abductions may be vivid dreams: study

Researchers say they have conducted "the first experiment to ever prove that close encounters with UFOs and extraterrestrials are a product of the human mind."

In a sleep study by the Out-Of-Body Experience Research Center in Los Angeles, 20 volunteers were instructed to perform a series of mental steps upon waking up or becoming lucid during the night that might lead them to have out-of-body experiences culminating in encounters with aliens.

According to lead researcher Michael Raduga, more than half the volunteers experienced at least one full or partial out-of-body experience, and seven of them were able to make contact with UFOs or extraterrestrials during these dream-like experiences.

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    4. Alien abductions may be vivid dreams: study

Raduga designed the experiment to test his theory that many reports of alien encounters are actually instances of people experiencing a vibrant, lifelike state of dreaming. If he could coach people to dream a realistic alien encounter, he said, that could prove that reports of such encounters are really just a product of our imaginations.

"When people experience alien abductions in the night, they usually don't know they are actually in REM sleep and having an out-of-body experience," Raduga told Life's Little Mysteries, adding than an estimated 1 million Americans have such experiences each year.

"It's very realistic and people cannot understand how it happens. [Our study] shows that it's not about aliens, it's about human abilities, and it can happen to almost anyone." [ 7 Things that Create Convincing UFO Sightings ]

Study participants were told to try to "separate from their bodies" every time they became half-awake or lucid during the night. If they were able to dream that they had separated from their sleeping bodies, they were then supposed to look for aliens in their homes. If they were unable to have an out-of-body dream experience, they were told to go back to sleep and try again later in the night.

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"Some could do it by the first attempt. Some needed three to five attempts to have an out-of-body experience.? Not everybody could do it ? some were unable to do it because of their fear. They were able to separate from their body but they became too afraid to look for aliens," Raduga said.

By the end of the study, 35 percent of the volunteers said they had made visual contact with aliens, and they described their encounters for the researchers.

One participant, identified as Alexander N., recalled making a successful attempt to separate from his body: "I [then] tried to find aliens. Three of them materialized right before my eyes. They seemed more like creatures from the movie 'The Thing' than tadpoles with eyes like Princess Jasmine. They wanted to scare me, not to 'make contact.' As a result, I was extremely frightened and regained awareness in my own body."

Raduga plans to publish his results and to conduct further studies on humans' ability to fabricate alien encounters that seem real.

Follow Natalie Wolchover on Twitter @ nattyover. Follow Life's Little Mysteries on Twitter @ llmysteries, then join us on Facebook.

Source: http://www.msnbc.msn.com/id/45051979/ns/technology_and_science-science/

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Storm forces NASA to call off underwater simulation (Reuters)

CAPE CANAVERAL, Florida (Reuters) ? NASA evacuated astronauts and scientists participating in an underwater space simulation in the Florida Keys over concerns about Hurricane Rina, officials said on Wednesday.

Six astronauts and scientists participating in the NASA Extreme Environment Mission Operations, or NEEMO, program left the Aquarius Undersea Laboratory after five days.

The start of the 15th NEEMO mission had been delayed by another storm in the area.

NASA said it will not reschedule the simulation, which was slated to last 13 days off the coast of Key Largo. The goals of the mission were to practice operations and test tools being developed for a future planned human mission to an asteroid.

Rina, a surprising late addition to the 2011 Atlantic hurricane season, was headed toward Mexico's Yucatan peninsula but losing strength on Wednesday.

Computer models forecast Rina, the sixth hurricane of the Atlantic season, will weaken into a tropical storm and move over western Cuba, potentially bringing strong winds and heavy rains to southern Florida and the Keys.

Participants in the NEEMO mission included NASA astronaut Shannon Walker, Japan's Takuya Onishi and Canada's David Saint-Jacques and scientists Steven Squyres with Cornell University and James Talacek and Nate Bender with the University of North Carolina at Wilmington.

The NEEMO crew conducted six underwater spacewalks and one day of scientific research. They also used a deep-water submersible to simulate robotic exploration of an asteroid.

"Despite the length, we accomplished a significant amount of research," NASA project manager Bill Todd said in a statement.

The next NEEMO mission is targeted for the summer of 2012. The 400 square-foot lab, which is about the size of a school bus, is anchored to the ocean floor near Key Largo at a depth of about 62 feet.

(Editing by Kevin Gray and Cynthia Osterman)

Source: http://us.rd.yahoo.com/dailynews/rss/space/*http%3A//news.yahoo.com/s/nm/20111026/sc_nm/us_space_hurricane

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Coroner: Winehouse died from alcohol

A coroner says Amy Winehouse died as the unintended consequence of drinking too much alcohol.

Coroner Suzanne Greenaway gave a verdict of "death by misadventure," saying the singer had voluntarily consumed alcohol and risked the consequences.

Story: Amy Winehouse's father is writing book

The singer, who had fought drug and alcohol problems for years, was found dead in bed at her London home on July 23 at age 27.

Slideshow: Amy Winehouse: 1983-2011 (on this page)

Pathologist Suhail Baithun told the singer's inquest Wednesday that Winehouse had consumed a "very large quantity of alcohol" and was more than five times over the legal drunk-driving limit when she died.

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The singer, who had fought drug and alcohol problems for years, was found dead in bed at her London home on July 23 at age 27.

An initial autopsy proved inconclusive, although it found no traces of illegal drugs in her system.

Story: Tony Bennett: Winehouse knew alcohol would kill her

Winehouse's doctor, Dr. Christina Romete, said the singer had resumed drinking in the days before her death after a period of abstinence.

Source: http://today.msnbc.msn.com/id/45045102/ns/today-entertainment/

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Westone's 4 R-Series quad-driver IEMs pack Acoustic Symmetry, cost $500

Remember those impressive Westone 4 in-ear monitors that came out late last year, priced at a whopping $450? Well, the company's ready to best itself again -- and have audiophiles open their wallets a bit wider -- with its new 4 R-Series. This latest set is relatively similar to the 4, still packing Westone's detachable EPIC cable and four balanced armature drivers, but will set you back an extra fifty bucks in the name of Acoustic Symmetry. Westone claims the 'phones achieve an "extremely tight tolerance of +/- 2dB between earpieces," meaning your sound should be extra consistent from both buds. The 4 R-Series buds are expected to arrive before the year's out, so in the meantime we'll just direct you to the PR past the break.

Continue reading Westone's 4 R-Series quad-driver IEMs pack Acoustic Symmetry, cost $500

Westone's 4 R-Series quad-driver IEMs pack Acoustic Symmetry, cost $500 originally appeared on Engadget on Mon, 24 Oct 2011 20:18:00 EDT. Please see our terms for use of feeds.

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Study shows Alzheimer's disease-related peptides form toxic calcium channels in the plasma membrane

Study shows Alzheimer's disease-related peptides form toxic calcium channels in the plasma membrane

Monday, October 24, 2011

Alzheimer's disease is triggered by the inappropriate processing of amyloid precursor protein to generate excess amounts of short peptide fragments called A-beta. For many years, the neurodegeneration associated with Alzheimer's disease was thought to be caused by the buildup of A-beta in insoluble, fibrous plaques. However, increasing suspicion now falls on smaller, soluble A-beta complexes as the toxic form of the protein, partly through their ability to induce excess calcium influx into cells, which disrupts synaptic signaling and stimulates cell death. A new study in The Journal of Cell Biology uses high-resolution imaging to reveal that A-beta oligomers elevate calcium by forming calcium-permeable pores in the plasma membrane.

A-beta oligomers could induce calcium influx by physically disrupting the cell's outer membrane or by activating endogenous calcium channels. But studies have also shown that A-beta peptides can form calcium-permeable pores themselves in both artificial and cell membranes. A limitation of experimental techniques used to date, says Angelo Demuro, from the University of California, Irvine, is that they only monitor the activity of one or two channels at a time. In addition, different groups have obtained disparate results regarding the properties of A-beta channels using this approach.

To overcome these problems, Demuro and colleagues developed an alternative method to measure the activity of calcium channels in living cells. "We can simultaneously record the behavior of thousands of channels using an imaging technique we call optical patch-clamping," Demuro explains. In this approach, frog eggs are filled with a calcium-sensitive dye, and the researchers observe the part of the cell nearest to the cell's outer membrane. When membrane channels open to let calcium into the cell, small fluorescent flashes indicate the duration and extent of calcium influx at each individual pore.

Demuro et al. found that, just twenty minutes after A-beta oligomers were added to the eggs, they displayed flickering spots of fluorescence signifying calcium influx through single membrane channels. This influx was unlikely to be through endogenous channels activated by A-beta because frog eggs barely express calcium channels of their own. Moreover, A-beta aggregates weren't simply disrupting the eggs' membrane, as the influx was inhibited by zinc ions, which block calcium-permeable pores.

A-beta oligomers therefore form calcium-permeable channels of their own in the membrane. Demuro and colleagues characterized the properties of these pores by simultaneously imaging the activity of thousands of channels in a single membrane region. "They are all different," says Demuro. "[The pores] show a wide variety of behaviors." Most pores opened infrequently and only let in small amounts of calcium, but some opened more often and channeled large amounts of calcium into the cell. Though few in number, Demuro et al.'s measurements suggest that this latter type of pore may be largely responsible for the toxic increase in cytoplasmic calcium levels.

Differences in the properties of individual pores may be caused by differences in the number of A-beta peptides assembled into each channel, with higher-order oligomers forming the more active species of pore. "It would be nice to visualize how many A-beta peptides each pore has and whether this is related to the activity of the channel," Demuro says. If pore activity is affected by the oligomerization state of A-beta, it appears that A-beta peptides continue to assemble after their insertion into membranes, as the pores became more active as eggs were exposed to A-beta oligomers for longer periods. This increase in calcium influx over time may be related to the gradual progression of Alzheimer's symptoms.

Beyond Alzheimer's disease, Demuro et al.'s approach may help explain the pathogenesis of other neurodegenerative disorders like Parkinson's and Huntington's disease, in which misfolded and aggregated proteins have also been reported to form calcium-permeable channels.

###

Rockefeller University Press: http://www.rupress.org/

Thanks to Rockefeller University Press for this article.

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Source: http://www.labspaces.net/114559/Study_shows_Alzheimer_s_disease_related_peptides_form_toxic_calcium_channels_in_the_plasma_membrane

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Oil hovers above $91 ahead of Europe debt plan (AP)

SINGAPORE ? Oil prices hovered above $91 a barrel Tuesday in Asia as investors await details of Europe's plan to contain its debt crisis.

Benchmark crude for December delivery was up 17 cents at $91.44 a barrel at midmorning Singapore time in electronic trading on the New York Mercantile Exchange. The contract rose $3.87, or 4.4 percent, to settle at $91.27 in New York on Monday.

Brent crude was down 20 cents at $111.25 a barrel on the ICE Futures Exchange in London.

Oil has jumped 21 percent in three weeks amid growing investor optimism that European leaders will devise a plan to limit the damage from a possible default of Greek sovereign debt. Details of the plan are expected to be announced Wednesday.

"Although the euro zone debt issue remains quite murky, the market appears to be pricing in a viable resolution to this crisis," energy consultant Ritterbusch and Associates said in a report. "Wednesday's EU summit could still bring some bearish news if a comprehensive debt plan is not forthcoming."

Crude has also rebounded this month because of signs global economic growth may not slow as much as some investors had previously expected. China, which has led global commodity demand growth in recent years, said Monday manufacturing likely improved in October from September.

Last week, China said its economy grew 9.1 percent in the third quarter.

"We continue to grow more positive on the outlook for China's commodity import demand over the remainder of the year," Barclays Capital said in a report. "Improving evidence from the macroeconomic front for October are in line with our soft landing assumptions."

In other Nymex trading, heating oil fell 1.1 cents to $3.04 per gallon and gasoline futures slid 1.0 cent at $2.66 per gallon. Natural gas was steady at $3.61 per 1,000 cubic feet.

Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20111025/ap_on_re_as/oil_prices

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Video: What is Occupy Wall Street?

3 cups of coffee a day keeps skin cancer away?

??Drinking copious amounts of coffee may reduce the risk of the most common type of skin cancer, a new study finds. Women in the study who drank more than three cups of coffee a day were 20 percent less likely to develop basal cell carcinoma.

Source: http://www.msnbc.msn.com/id/3036697/vp/45023192#45023192

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Earth Officially Home To 7 Billion Humans

New submitter arcite writes "It's official: planet Earth is now home to over seven billion ugly-bags-of-mostly-water (otherwise known as humans). We're adding ten thousand new humans every hour, or one billion every nine years. Head over to 7 Billion Actions (put together by the UN with the help of SAP) and check out the population map data. Short of adopting a strict diet of Soylent Green, what viable solutions will enable us to survive on this increasingly crowded pale blue dot? What will the role of technology be in supporting this many people?"

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/L_QuRIm3CN8/earth-officially-home-to-7-billion-humans

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